Notes for: Antithyroid DrugsLast edited [11/05/2012 11:33:50]
CSM Warning
1. Carbimazole and propylthiouracil may induce neutropenia and agranulocytosis which warrant prompt cessation of treatment. Patients should be asked to report symptoms and signs suggesting infection including sore throat (written and verbal warning of this potential complication should be given - an example is provided in the following information sheet). If there is clinical evidence of infection a WBC count should be performed. If clinical or laboratory evidence suggests neutropenia carbimazole and propylthiouracil should be stopped.
2. Propylthiouracil is used where there is a known sensitivity to carbimazole and is preferred in pregnancy.