Notes for: SulfonylureasLast edited [11/05/2012 10:08:18]
1. Oral antidiabetic preparations should be considered only if poor control and symptoms persist after appropriate dieting.
2. Sulphonylureas should be given 30 minutes before food. Sulphonylureas may promote weight gain. They are contraindicated in pregnancy.
3. Gliclazide is the preferred choice in those patients with renal impairment as it is shorter acting and principally inactivated in the liver.
4. Glimepiride may be considered in patients for whom gliclazide is unsuitable.
5. Glibenclamide is not included in the formulary because its long half-life (often extended in the elderly) may cause hypoglycaemia.
6. Chlorpropamide is not recommended.